| Team Ranking | Overall | Rushing | Passing |
| Offense | 11th | 155.7 (4th) | 206.1 (23rd) |
| Defense | 3rd | 94.2 (4th) | 200.2 (4th) |
| Date | Player | Pos. | Description |
| 5/22 | Aldon Smith | LB | Questionable for start of training camp |
| 5/10 | Marcus Lattimore | RB | Doubtful for 2013 season |
| 4/01 | Kendall Hunter | RB | Probable for start of training camp |
| 4/22 | Larry Grant | LB | Eligible to return Week 5 vs. Houston |
| 3/13 | Kyle Williams | WR | Questionable for start of training camp |
| Full injuries report | |||
| Date | Player | Pos. | Description |
| 5/22 | Quinton Patton | WR | signed/draft choice, Four-year contract (through 2016) |
| 5/21 | Kyle Nelson | TE | acquired from waivers |
| 5/21 | Anthony Santella | P | cut |
| 5/14 | Jason Schepler | RB | signed |
| 5/10 | Quinton Dial | DT | signed/draft choice, Four-year contract (through 2016) |
| Complete 49ers Transactions | |||
| NFC West | |||||||
| Team | W | L | T | PF | PA | DIV | Streak |
| z-San Francisco | 11 | 4 | 1 | 397 | 273 | 3-2-1 | Won 1 |
| x-Seattle | 11 | 5 | 0 | 412 | 245 | 3-3 | Won 5 |
| St. Louis | 7 | 8 | 1 | 299 | 348 | 4-1-1 | Lost 1 |
| Arizona | 5 | 11 | 0 | 250 | 357 | 1-5 | Lost 2 |
| Complete Standings | |||||||
| 2013 Schedule | Buy 49ers Tickets |
| Date | Opponent | Time/Result |
| Sep 8 | Green Bay | 4:25 pm |
| Sep 15 | @Seattle | 8:30 pm |
| Sep 22 | Indianapolis | 4:25 pm |
| Sep 26 | @St. Louis | 8:25 pm |
| Oct 6 | Houston | 8:30 pm |
| Oct 13 | Arizona | 4:25 pm |
| Oct 20 | @Tennessee | 4:05 pm |
| Oct 27 | @Jacksonville (London, England) | 1:00 pm |
| Week 9 | BYE | |
| Nov 10 | Carolina | 4:05 pm |
| Nov 17 | @New Orleans | 4:25 pm |
| Nov 25 | @Washington | 8:40 pm |
| Dec 1 | St. Louis | 4:05 pm |
| Dec 8 | Seattle | 4:25 pm |
| Dec 15 | @Tampa Bay | 1:00 pm |
| Dec 23 | Atlanta | 8:40 pm |
| Dec 29 | @Arizona | 4:25 pm |
| All times are Eastern | ||
| Complete Schedules | ||
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